Orexin, cardio-respiratory function, and hypertension

Orexin, cardio-respiratory function, and hypertension

In this review we focus on the role of orexin in cardio-respiratory functions and its potential link to hypertension. (1) Orexin, cardiovascular function, and hypertension. In normal rats, central administration of orexin can induce significant increases in arterial blood pressure (ABP) and sympathetic nerve activity (SNA), which can be blocked by orexin receptor antagonists. In spontaneously h...

Salt Sensitive Hypertension and Orexin

Pulmonary emphysema, cardio-respiratory disturbance.

Pulmonary emphysema, as the term is generally used clinically, refers to an overinfiation or distention of the lungs (localized or diffuse), characterized by a relative increase in the amount of air which cannot be blown out with a forced expiration. The residual air capacity plus the vital capacity equals total observed lung capacity (TLC) for the individual, and in pulmonary emphysema the TLC...

Developmental Mismatch – consequences for later cardio-respiratory health Running title: Developmental mismatch & cardio-respiratory health

Clinical and epidemiological studies have established that people who were small at birth and had poor infant growth have an increased risk of adult cardiovascular and respiratory disease, particularly if their restricted early growth is followed by accelerated childhood weight gain. This relationship extends across the normal range of infant size in a graded manner. The ‘mismatch hypothesis’, ...

Tonic and reflex control of the cardio-respiratory system by neurons in the ventral medulla

To investigate the channels and neurotransmitters in the ventrolateral medulla (VLM) oblongata that are responsible for the maintenance of sympathetic tone and cardio-respiratory reflex regulation. Microinjections of excitant amino acid (glutamate, 100 nl, 100 mM), calcium channel blockers, agonists and antagonists were made throughout the VLM in anaesthetized rats. Arterial blood pressure, sym...